https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12691 2 rebreathing method, however, still suffers from relatively poor accuracy at rest, and gated pool radionuclide scanning requires high levels of medical technological expertise under confined laboratory conditions. Impedance cardiography (IC) does not suffer from these disadvantages. We have evaluated the accuracy of impedance cardiography against accepted invasive methods e.g. thermodilution (TD), dye dilution (DD), the electromagnetic flowmeter (EM), in models where different degrees of experimental control could be applied. This approach was necessary due to the empirical aspects of the Kubicek formula for the calculation of stroke volume using IC. In addition, we have assessed the accuracy of the independent methods in clinical usage, as the assessment of accuracy of impedance cardiography would depend to some extent on the accuracy of the independent method used. Using regression analysis of simultaneous estimates of SV and CO, the accuracy of TD (against EM) in rabbits is 1.0% (S.E. of a single CO estimate expressed as % of mean CO (492 ± 3.5 ml), and that of IC SV measurements in the dog (against EM) is 1.7% (22.2 ± 0.4ml). In man, the accuracy of right heart thermodilution SV measurements (against DD) is 3.9% (75.4 3.0ml), and that for IC SV measurements (against TD) is 2.1 % (58.2 ± 1.2ml). These results indicate that both the invasive TD, and the non-invasive IC systems used in our laboratories have comparable and satisfactory accuracies for SV measurement, and suggest that under conditions of normal hearts and lungs, IC is useful for accurate and continuous non-invasive stroke volume measurements in exercising man, provided certain conditions of usage are satisfied.]]> Wed 24 Jul 2013 22:25:16 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23230 Wed 24 Aug 2016 17:36:49 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22250 Wed 11 Apr 2018 17:20:41 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24142 Wed 11 Apr 2018 16:06:55 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14369 Wed 11 Apr 2018 15:26:38 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15202 Wed 11 Apr 2018 15:20:44 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16548 Wed 11 Apr 2018 15:11:04 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9507 Wed 11 Apr 2018 15:10:10 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14210 Wed 11 Apr 2018 15:00:30 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4536 Wed 11 Apr 2018 14:58:14 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14744 Wed 11 Apr 2018 14:16:29 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9434 Wed 11 Apr 2018 14:12:24 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4343 Wed 11 Apr 2018 13:57:51 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15724 Wed 11 Apr 2018 13:57:46 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25999 Wed 11 Apr 2018 13:43:11 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9433 Wed 11 Apr 2018 13:04:58 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6374 Wed 11 Apr 2018 11:49:34 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9432 Wed 11 Apr 2018 10:51:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15802 Wed 11 Apr 2018 10:11:52 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1820 =65 years of age. Case-fatality rates showed similar trends with a 1- to 2-month lag compared with attack rates. Conclusions: There is an increase in stroke attack rates and case-fatality rate from summer to winter in the Hunter Region, Australia. These trends are similar to those found in the Northern Hemisphere.]]> Wed 11 Apr 2018 09:35:35 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13946 Wed 11 Apr 2018 09:27:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16806 Tue 24 Aug 2021 14:40:46 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14209 Tue 24 Aug 2021 14:39:08 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16097 Tue 24 Aug 2021 14:26:09 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19652 12 months, with the final meeting occurring during the Stroke Treatment Academy Industry Roundtable (STAIR) on March 9 to 10, 2013, in Washington, DC. This process brought together vascular neurologists, neuroradiologists, neuroimaging research scientists, members of the National Institute of Neurological Disorders and Stroke, industry representatives, and members of the US Food and Drug Administration to discuss stroke imaging research priorities, especially in the light of the recent negative results of acute stroke clinical trials that tested the concept of penumbral imaging selection. The goal of this process was to propose a research roadmap for the next 5 years. STIR recommendations include (1) the use of standard terminology, aligned with the National Institute of Neurological Disorders and Stroke Common Data Elements. ; (2) a standardized imaging assessment of revascularization in acute ischemic stroke trials, including a modified Treatment In Cerebral Ischemia (mTICI) score. ; (3) a standardized process to assess whether ischemic core and penumbral imaging methods meet the requirements to be considered as an acceptable selection tool in acute ischemic stroke trials. ; (4) the characteristics of a clinical and imaging data repository to facilitate the development and testing process described in recommendation no. 3. ; (5) the optimal study design for a clinical trial to evaluate whether advanced imaging adds value in selecting acute ischemic stroke patients for revascularization therapy. ; (6) the structure of a stroke neuroimaging network to implement and coordinate the recommendations listed above. All of these recommendations pertain to research, not to clinical care.]]> Thu 28 May 2020 06:30:04 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:656 Thu 25 Jul 2013 09:10:28 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:654 Thu 25 Jul 2013 09:10:27 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:509 140/90 mmHg at the initial screening visit, 898 (24%) were not eligible for study entry after two further visits due to the elevated reading not being sustained. For both systolic and diastolic blood pressure recording, observed digit preference fell within 7 percentage points of the expected frequency. Protocol adherence, in terms of the required minimum blood pressure difference between the last two successive recordings, was 99.8%. These data suggest that adherence to blood pressure recording protocols and elimination of digit preferences can be achieved through appropriate training programs and quality control activities in large multi-centre community-based trials in general practice. Repeated blood pressure measurement prior to initial diagnosis and study entry is essential to appropriately characterize hypertension in these elderly patients.]]> Thu 25 Jul 2013 09:10:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7458 1.2 and perfusion deficit at least 10 mL>DWI volume) and CDM (NIHSS ≥8 and DWI volume ≤25 mL) was determined for each patient. We assessed lesion growth and neurological improvement (decrease in NIHSS ≥8 points between baseline and 90 days, or a 90-day NIHSS ≤1). Results: 86% of the patients had PDM, but only 41% had CDM. CDM detected PDM with a sensitivity of 46% and a specificity of 86%. We found statistically significant effects of reperfusion on the rate of neurological improvement (OR 9.92, 95% CI 1.91 to 51.64; P<0.01) and on absolute growth (difference: –59.60 mL, 95% CI –95.40 mL to –23.81 mL; P<0.01). Neither treatment with tPA nor reperfusion had a significantly different impact on lesion growth or clinical course in CDM patients compared to patients without CDM. Conclusions: There was no increased benefit from tPA in patients with CDM. The beneficial effects of reperfusion were similar in patients with and without CDM.]]> Sat 24 Mar 2018 10:46:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13753 Sat 24 Mar 2018 10:39:17 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11084 Sat 24 Mar 2018 10:33:37 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6925 Sat 24 Mar 2018 08:40:25 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7389 Sat 24 Mar 2018 08:40:12 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9581 Sat 24 Mar 2018 08:39:12 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7482 Sat 24 Mar 2018 08:38:48 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:8171 Sat 24 Mar 2018 08:36:05 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9509 Sat 24 Mar 2018 08:35:31 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9555 1.2, was independently scored by 1 expert and 2 inexperienced raters blinded to calculated volumes and clinical information. Visual mismatch was compared with region-of-interest-based volumetric calculation, which was used as the gold standard. Results: Volumetric calculation demonstrated perfusion-diffusion mismatch in 85/99 patients. Visual TTP-DWI mismatch was correctly classified by the experienced rater in 82% of the cases (sensitivity: 0.86; specificity: 0.54) compared to 73% for the inexperienced raters (sensitivity: 0.75; specificity: 0.57). The interrater reliability for TTP-DWI mismatch was moderate (к= 0.50). Visual T max -DWI mismatch performed better (agreement – 93 and 87%, sensitivity – 95 and 88%, specificity – 77 and 82% for the experienced and inexperienced raters, respectively). Conclusions: The assessment of visual TTP-DWI mismatch at the MRI console is insufficiently reliable for use in clinical trials. Differences in perfusion analysis technique and visual inaccuracies combine to make visual TTP-DWI mismatch substantially different to volumetric T max -DWI mismatch. Automated software that applies perfusion thresholds may improve the reproducibility of real-time mismatch assessment.]]> Sat 24 Mar 2018 08:34:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:8092 Sat 24 Mar 2018 08:34:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7118 Sat 24 Mar 2018 08:34:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7969 Sat 24 Mar 2018 08:33:40 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1947 Sat 24 Mar 2018 08:33:19 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1304 =1 established stroke risk factor, but only 409 (49.8%) respondents correctly listed >=1 warning sign. Conclusions: The level of knowledge in the community of established stroke risk factors, warning signs, and treatment as indicated by this survey suggests that a community-based education program to increase public knowledge of stroke may contribute to reducing the risk of stroke and to increasing the speed of hospital presentation after the onset of stroke.]]> Sat 24 Mar 2018 08:32:43 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:2292 Sat 24 Mar 2018 08:26:57 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14319 Sat 24 Mar 2018 08:26:22 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14102 Sat 24 Mar 2018 08:24:01 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14582 Sat 24 Mar 2018 08:22:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16030 Sat 24 Mar 2018 08:21:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12891 Sat 24 Mar 2018 08:17:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10952 Sat 24 Mar 2018 08:14:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10516 Sat 24 Mar 2018 08:13:56 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10646 Sat 24 Mar 2018 08:13:40 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10818 Sat 24 Mar 2018 08:13:37 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10667 Sat 24 Mar 2018 08:12:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11142 Sat 24 Mar 2018 08:10:28 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10798 Sat 24 Mar 2018 08:10:05 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11951 Sat 24 Mar 2018 08:09:41 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10559 Sat 24 Mar 2018 08:08:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10749 Sat 24 Mar 2018 08:08:20 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10748 Sat 24 Mar 2018 08:08:19 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10907 Sat 24 Mar 2018 08:07:41 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20453 Sat 24 Mar 2018 08:06:58 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16723 Sat 24 Mar 2018 08:05:31 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21404 n=3467, mean age 74 years [standard deviation 13], 50% female; intracerebral haemorrhage n=275, mean age 74 years [standard deviation 13], 48% female). Following multivariable analyses patients with intracerebral haemorrhage were less likely to be admitted to a stroke unit (adjusted odds ratio 0·65; 95% confidence interval 0·45-0·94) or receive an assessment from allied health (adjusted odds ratio 0·54; 95% confidence interval 0·33-0·89) than patients with ischemic stroke. Patients with intracerebral haemorrhage are also less likely to be independent (adjusted odds ratio 0·36; 95% confidence interval 0·3-0·5) at time of hospital discharge and had a greater odds of dying in hospital (adjusted odds ratio 2·1; 95% confidence interval 1·3-3·5). Patients that were admitted to a stroke unit had a greater odds of being independent (modified Rankin Score 0-2) at day 7-10 irrespective of stroke type or severity on admission (adjusted odds ratio 1·3; 95% confidence interval 1·01-1·66). Conclusions: Following intracerebral haemorrhage, patients were less likely to be admitted to an acute stroke unit and receive allied health interventions. Admission to stroke units improved the likelihood of being independent at days 7-10 and, therefore, more should be done to encourage evidence-based care for intracerebral haemorrhage.]]> Sat 24 Mar 2018 08:04:59 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18235 Sat 24 Mar 2018 08:04:53 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18166 50% of neurons within the sample. To determine whether FMISO retention occurred after the tissue was already committed to infarction, FMISO was administered 4 to 6 hours after the onset of permanent vessel occlusion. Intense FMISO retention was consistently seen throughout the infarct core. In conclusion, FMISO retention occurs both within the ischaemic penumbra and within the early infarct core. Most penumbral tissues show evidence of selective cellular injury.]]> Sat 24 Mar 2018 08:04:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18267 Sat 24 Mar 2018 08:04:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19897 2peak) assessed preintervention and postintervention via a progressive aerobic exercise test. Results: From 3209 citations identified, 28 studies were included, reporting results for 920 participants. Studies typically included chronic, ambulant participants with mild to moderate deficits; used an aerobic or mixed (with an aerobic component) intervention; and prescribed 3 sessions per week for 30 to 60 minutes per session at a given intensity. Baseline VO_2peak values were low (8-23 mL/kg/min). Meta-analysis of the 12 randomized controlled trials demonstrated overall improvements in VO_2peak of 2.27 (95% confidence interval = 1.58, 2.95) mL/kg/min postintervention. A similar 10% to 15% improvement occurred with both aerobic and mixed interventions and in shorter (≤3 months) and longer (>3 months) length programs. Only 1 study calculated total dose received and only 1 included long-term follow-up. Conclusions: The results demonstrate that interventions with an aerobic component can improve cardiorespiratory fitness poststroke. Further investigation is required to determine effectiveness in those with greater impairment and comorbidities, optimal timing and dose of intervention, whether improvements can be maintained in the longer term, and whether improved fitness results in better function and reduced risk of subsequent cardiovascular events.]]> Sat 24 Mar 2018 08:03:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17247 Sat 24 Mar 2018 08:01:21 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21854 Sat 24 Mar 2018 07:59:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18973 Sat 24 Mar 2018 07:58:53 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21817 Sat 24 Mar 2018 07:58:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19580 Sat 24 Mar 2018 07:58:19 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20370 Sat 24 Mar 2018 07:58:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17678 Sat 24 Mar 2018 07:57:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16968 Sat 24 Mar 2018 07:55:25 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16967 Sat 24 Mar 2018 07:55:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16870 Sat 24 Mar 2018 07:54:47 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19971 Sat 24 Mar 2018 07:54:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21327 Sat 24 Mar 2018 07:52:51 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21652 Sat 24 Mar 2018 07:52:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19423 −/− Vim ^−/−) do not form cytoplasmic intermediate filaments. GFAP ^−/− Vim ^−/− mice develop larger infarcts after ischemic stroke (Li et al. in J Cereb Blood Flow Metab 28(3):468–481, 2008). Here, we attempted to analyze the underlying mechanisms using oxygen–glucose deprivation (OGD), an in vitro ischemia model, examining a potential link between astrocyte intermediate filaments and reactive oxygen species (ROS). We observed a reorganization of the intermediate filament network in astrocytes exposed to OGD. ROS accumulation was higher in GFAP ^−/− Vim ^−/− than wild-type astrocytes when exposed to OGD followed by reperfusion or when exposed to hydrogen peroxide. These results indicate that the elimination of ROS is impaired in the absence of the intermediate filament system. Compared to wild-type astrocytes, GFAP ^−/− Vim ^−/− astrocytes exposed to OGD and reperfusion exhibited increased cell death and conferred lower degree of protection to cocultured neurons. We conclude that the astrocyte intermediate filament system is important for the cell response to oxidative stress induced by OGD followed by reperfusion.]]> Sat 24 Mar 2018 07:51:56 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20171 Sat 24 Mar 2018 07:51:43 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18522 Sat 24 Mar 2018 07:50:20 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27840 Sat 24 Mar 2018 07:41:16 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27872 Sat 24 Mar 2018 07:41:12 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28647 P<0.0001, r=−0.7, r²=0.53; SIS recovery n=2970, P<0.0001, r=−0.71, r²=0.52). Proxy responses had a stronger association with BI (EQ-5D weighted score n=837, P<0.0001, r=0.78, r²=0.63; SIS recovery n=867, P<0.0001, r=0.68, r²=0.48). mRS explained more of the variation in QoL (EQ-5D weighted score=53%, recovery by SIS v3.0=52%) than NIHSS or BI and resulted in fewer mismatches between good primary outcome and poor QoL (P<0.0001, EQ-5D weighted score=8.5%; SIS recovery=10%; SIS-16=4.4%). Conclusions: The mRS seemed to align closely with stroke survivors’ interests, capturing more information on QoL than either NIHSS or BI. This further supports its recommendation as a primary outcome measure in acute stroke randomized controlled trials.]]> Sat 24 Mar 2018 07:37:14 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28656 n = 100) for five-months following hospital discharge after stroke (plus usual care) and compared with usual care (n = 101). Ethical approval was obtained to withhold information about the intervention and primary outcome from participants during the consent process. Results: No significant difference was seen in the proportion of participants with depression in the intervention group (1/88) vs. the control group (3/76) (relative risk 0·29, 95% confidence interval 0·03–2·71) at six-months. No significant differences were seen on Hospital Anxiety Depression Scale (HADS) depression and anxiety sub-scale scores, quality of life, or activities of daily living; however, many (47/100) responded positively to the postcards. Conclusions: Although this simple postcard intervention did not significantly reduce the proportion of participants experiencing high HADS depression sub-scale scores after stroke, it may be an effective way to engage with people after stroke following hospital discharge.]]> Sat 24 Mar 2018 07:37:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28540 Sat 24 Mar 2018 07:28:47 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28358 –8) with 1 or more coagulation/fibrin phenotypes. The most striking associations included SNP rs5985 with factor XIII activity (p = 2.6 x 10^–186), rs10665 with FVII (p = 2.4 x 10^–47), and rs505922 in the ABO gene with both von Willebrand factor (p = 4.7 x 10^–57) and factor VIII (p = 1.2 x 10^–36). In Stage 2, the 23 independent SNPs were examined in stroke cases/noncases using MOnica Risk, Genetics, Archiving and Monograph (MORGAM) and Wellcome Trust Case Control Consortium 2 collections. SNP rs505922 was nominally associated with ischemic stroke (odds ratio = 0.94, 95% confidence interval = 0.88–0.99, p = 0.023). Independent replication in Meta-Stroke confirmed the rs505922 association with stroke, beta (standard error, SE) = 0.066 (0.02), p = 0.001, a finding specific to large-vessel and cardioembolic stroke (p = 0.001 and p = < 0.001, respectively) but not seen with small-vessel stroke (p = 0.811). Interpretation: ABO gene variants are associated with large-vessel and cardioembolic stroke but not small-vessel disease. This work sheds light on the different pathogenic mechanisms underpinning stroke subtype. Ann Neurol 2013]]> Sat 24 Mar 2018 07:25:12 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28765 P<0.15 or if considered clinically important and readmission status. Results: Among 3328 patients, 6.5% were readmitted within 28 days (mean age, 75; 48% female; 92% ischemic). After bivariate analyses 14/43 factors from 4/5 categories were associated with readmission after hospitalization for stroke. Two factors from patient and health outcome categories remained independently associated with readmission after multivariable analyses. These were dependent premorbid functional status (adjusted odds ratio, 1.87; 95% confidence interval, 1.25–2.81) and having a severe adverse event during the initial hospitalization for stroke (adjusted odds ratio, 2.81; 95% confidence interval, 1.55–5.12). Conclusions: This is the first study to comprehensively evaluate factors associated with 28-day readmission after stroke. The factors associated with 28-day readmission are diverse and include potentially modifiable and nonmodifiable factors.]]> Sat 24 Mar 2018 07:24:50 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4660 Sat 24 Mar 2018 07:19:34 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4662 Sat 24 Mar 2018 07:19:34 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4661 Sat 24 Mar 2018 07:19:33 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4666 Sat 24 Mar 2018 07:19:33 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25200 Sat 24 Mar 2018 07:14:02 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23590 Sat 24 Mar 2018 07:13:22 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23450 Sat 24 Mar 2018 07:13:02 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23824 1·2, and absolute mismatch >10 ml) will be randomized to either tissue plasminogen activator or placebo. Study outcome: The primary outcome measure will be modified Rankin Scale 0–1 at day 90. Clinical secondary outcomes include categorical shift in modified Rankin Scale at 90 days, reduction in the National Institutes of Health Stroke Score by 8 or more points or reaching 0–1 at day 90, recurrent stroke, or death. Imaging secondary outcomes will include symptomatic intracranial haemorrhage, reperfusion and or recanalization at 24 h and infarct growth at day 90.]]> Sat 24 Mar 2018 07:12:50 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23766 Sat 24 Mar 2018 07:11:08 AEDT ]]>